Chicago White Sox at Chicago Cubs odds, picks and predictions (2024)

The Chicago White Sox (15-46) battle the Chicago Cubs (30-31) in the finale of a short 2-game series Wednesday. First pitch from Wrigley Field is scheduled for 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’slines around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 1-0

The White Sox have lost 12 games in a row after falling 7-6 Tuesday as +247 road underdogs. DH Korey Leeand 3BLenyn Sosaeach had 2 RBIs during a 5-run 4th inning as the Sox jumped out to a 5-0 lead.

After the Cubs tied it in the bottom of the 6th, CF Luis Robert Jr. put the Sox back in front with a solo homer in the 7th, but Cubs LF Ian Happhit a 2-run, go-ahead double in the 8th for the final score. PH/1B Patrick Wisdom and 3B Christopher Morel both homered as the Cubs (-278) fought their way back, helping the Over (9.5) hit.

White Sox at Cubs projected starters

RHP Erick Fedde vs. RHP Jameson Taillon

Fedde (4-1, 3.12 ERA) makes his 13th start. He has a 1.18 WHIP, 2.9 BB/9 and 8.6 K/9 through 69 1/3 innings.

• Last start: No-decision, 5 IP, 4 ER, 9 H, 4 BB, 8 K in 12-5 loss at Milwaukee Brewers Friday
• White Sox are 5-7 in his 12 starts with Fedde allowing 4 or more ER in 2 of his last 3 outings
• Career vs. Cubs: 0-0, 5.56 ERA (11 1/3 IP, 7 ER), 12 H, 5 BB, 15 K in 2 starts — last outing in 2021

Taillon (3-2, 2.84 ERA) makes his 9th start. He has a 1.26 WHIP, 2.4 BB/9 and 5.9 K/9 through 44 1/3 innings.

• Last start: No-decision, 6 IP, 3 ER, 6 H, 1 BB, 4 K in 6-4 loss at Brewers Thursday
• Cubs are 4-4 in his 8 starts, but they are 0-4 in his last 4. He has allowed 3 ER in each of his last 3 outings
• Career vs. White Sox: 0-0, 2.38 ERA (22 2/3 IP, 6 ER), 1.15 WHIP, 7.9 K/9 in 4 starts

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White Sox at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:10 a.m. ET.

• Moneyline (ML): White Sox +145 (bet $100 to win $145) | Cubs -175 (bet $175 to win $100)
• Run line (RL)/Against the spread (ATS): White Sox +1.5 (-130) | Cubs -1.5 (+105)
• Over/Under (O/U): 9 (O: -120 | U: +100)

White Sox at Cubs picks and predictions

Prediction

Cubs 6, White Sox 4

Moneyline

BET CUBS (-175).

While the White Sox have lost 12 in a row, the Cubs are just 3-9 in their last 12 games. The Cubs still have a clear advantage, however with Taillon on the mound, in which the Cubs have lost his last 4 starts, and less profit to be made on a win, do not make a large wager on the outcome.

Run line/Against the spread

PASS.

With both teams at a combined 3-21 over each of their last 12 games, it is evident neither team has played well enough to merit a bet on the run line. Both have struggled defensively and only seen minimal success on offense.

Over/Under

BET OVER 9 (-120).

The Over is 5-3-2 in the last 10 games for the White Sox, including in back-to-back outings. The pitching staff has allowed 4 or more runs in 11 of its last 12, and 5 or more in 9 of those 12.

The Cubs have hit the Over in 7 of their last 10, including 6 of their last 7. They have scored 4 or more in 6 of their last 7, and 6 or more in 4 of their last 7, while allowing 5 or more in 8 of their last 10.

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